Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia

Introduction: Nausea and vomiting is one of the complications of spinal anesthesia in cesarean section. The aim of this study was to compare the effects of dexamethasone-metocloprmide with ondansetrone on preventing nausea and vomiting during spinal Anesthesia for cesarean section. Methods: In this study 212 pregnant women (17-45 years old) candidate for elective cesarean section with an ASA I-II were subjected to a randomized double blind clinical trial. Before spinal anesthesia was applied the first group received 8 milligram dexamethasone and 10 milligram metoclopramide intravenously, the second group received 8 milligram ondansetrone intravenously. Correspondence: Saeed Kashani, MD. Anesthesiology Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences. Bandar Abbas, Iran Tel:+98 9177614110 Email: [email protected] Results: There were no significant differences between the two groups regarding the demographic variables, and also heart rate, systolic and diastolic blood pressures at before neuroaxial block and at 1, 3, 5 and 10 minutes after block. )P>0.05). The Apgar score between the two groups was significantly different at the first (P=0.028), fifth (P=0.001) and twentieth minute (P=0.019). The overall incidence of nausea was 11.3% with no significant difference between the groups (P=0.665). No patient in the dexamethasone-metocloprimde group experienced any vomiting and in the ondansetrone group only 5 patients (4.7%) had vomiting (P>0.05). Conclusion: The combination of dexamethasone and metocloprimde is effective in preventing nausea and vomiting during cesarean section in women who have no other pregnancy related complications